Asymmetric synthesis of all the stereoisomers of tarchonanthuslactone |
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Authors: | S Baktharaman |
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Institution: | Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, India |
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Abstract: | We describe herein an efficient synthesis of all the four stereoisomers of tarchonanthuslactone from (R)-3-hydroxy butanoate, easily prepared from l-threonine. The approach involves the use of a β,γ-unsaturated δ-lactone as an intermediate, obtained via a Kulinkovich reaction followed by a ring-closing metathesis strategy. |
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Keywords: | Tarchonanthuslactone Asymmetric synthesis Kulinkovich reaction RCM |
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