Synthesis of a new hydrophilic o-nitrobenzyl photocleavable linker suitable for use in chemical proteomics |
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| Authors: | Andrew M Piggott |
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| Institution: | Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney NSW 2109, Australia |
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| Abstract: | Linkers currently used in solid phase synthesis are generally short and hydrophobic, limiting their usefulness in biological systems. Herein, we describe a facile synthesis of a long, hydrophilic, o-nitrobenzyl photocleavable linker, suitable for constructing affinity supports for use in chemical proteomics. The rates of photolysis of the linker on exposure to UV light emitting diodes are reported. |
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| Keywords: | Photocleavable Photolabile Linker o-Nitrobenzyl 2-Nitrobenzyl Chemical proteomics Affinity support UV LED |
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