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Antimycobacterial natural products: synthesis and preliminary biological evaluation of the oxazole-containing alkaloid texaline |
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| Authors: | Anna C. Giddens Scott G. Franzblau Brent R. Copp |
| Affiliation: | a Department of Chemistry, University of Auckland, Private Bag 92019, Auckland, New Zealand b Tuberculosis Research Section, NIH-NIAID, 12441 Parklawn Dr., Rockville, MD 20852, USA c Institute for Tuberculosis Research, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA |
| Abstract: | Texaline, an antimycobacterial oxazole-containing alkaloid previously isolated from Amyris texana and A. elemifera, and related compounds have been synthesized in order to explore aspects of the structure-antituberculosis activity relationship. While texaline was found to be inactive in our assays, simpler diaryloxazoles were more active whilst also exhibiting modest toxic selectivity, leading to their identification as potential lead compounds. |
| Keywords: | Texaline Alkaloid Tuberculosis Natural product |
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