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A reliable synthesis of 2- and 6-amino-β-cyclodextrin and permethylated-β-cyclodextrin |
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| Authors: | I. Wayan Muderawan Teck Chia Lee Chi Bun Ching |
| Affiliation: | a Division of Chemical and Biomolecular Engineering, Nanyang Technological University, Singapore 639798, Singapore b Institute of Chemical and Engineering Sciences Ltd, 1 Pesek Road, Jurong Island, Singapore 627833, Singapore c School of Science, Griffith University, Nathan 4111, Australia |
| Abstract: | A new, reliable method for the introduction of an amine group at positions 2 or 6 of β-cyclodextrin and permethyl-β-cyclodextrin is described. It involves selective tosylation followed by azide substitution and almost quantitative reduction with triphenylphosphine followed by hydrolysis of the phosphinimine intermediate. |
| Keywords: | Modified cyclodextrin Amino β-cyclodextrin Amino permethyl-β-cyclodextrin |
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