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Microwave-promoted synthesis of chiral pyridinium salts |
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| Authors: | Gustavo HR Viana Rosemeire B Alves Christian Marazano |
| Institution: | a Departamento de Química, Instituto de Ciências Exatas, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31270-901 Belo Horizonte, Brazil b Departamento de Química, ICEB, UFOP, Campus Morro do Cruzeiro, Ouro Preto, MG, Brazil c Institut de Chimie des Substances Naturelles, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France |
| Abstract: | The synthesis of several chiral pyridinium salts via Zincke’s reaction can be easily accomplished by domestic microwave oven irradiation. Yield enhancements, reduction of reaction time, and less racemization were observed under microwave heating when compared to conventional heating in similar conditions. |
| Keywords: | Asymmetric synthesis Amino alcohols Pyridines Microwave irradiation Zincke&rsquo s reaction |
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