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Nitric acid in the presence of P2O5 supported on silica gel—a useful reagent for nitration of aromatic compounds under solvent-free conditions
Authors:Abdol Reza Hajipour  Arnold E Ruoho
Institution:a Pharmaceutical Research Laboratory, Department of Chemistry, Isfahan University of Technology, Isfahan 84156, Iran
b Department of Pharmacology, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 53706-1532, USA
Abstract:A variety of aromatic compounds are nitrated to parent nitro aromatic compounds under solvent-free conditions using 65% nitric acid in the presence of P2O5 supported on silica gel is described. This methodology is useful for nitration of activated and deactivated aromatic rings.
Keywords:Nitration  Solvent free  Silica gel  P2O5  HNO3
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