Design, synthesis, and validation of rigid linkers for bioactive peptides |
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| Authors: | Yasunari Monguchi Heather L Handl Lucinda J Begay Robert J Gillies |
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| Institution: | a Department of Chemistry, The University of Arizona, Tucson, AZ 85721-0041, USA
b Department of Biochemistry and Molecular Biophysics, The Arizona Cancer Center, Tucson, AZ 85724-5024, USA |
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| Abstract: | Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor. |
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