1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) catalyzed Michael reactions |
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Authors: | Weiping Ye |
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Institution: | Department of Chemistry, 3 Science Drive 3, National University of Singapore, Singapore 117543, Singapore |
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Abstract: | 1,5,7-Triazabicyclo4.4.0]dec-5-ene (TBD), a bicyclic guanidine base, has been found to be an excellent catalyst for Michael and Michael-type reactions. A wide variety of Michael donors and acceptors can participate in these reactions using 10-20 mol % of TDB. These reactions are mild, fast, easy to perform, produce excellent yields and can occur in several solvents without the need for strictly anhydrous conditions. |
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Keywords: | TBD Michael reaction Organobase |
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