Reductive sulfur extrusion reaction of 2,1,3-benzothiadiazole compounds: a new methodology using NaBH4/CoCl2·6H2O(cat) as the reducing system |
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| Authors: | Brenno A DaSilveira Neto Jairton Dupont |
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| Institution: | Laboratory of Molecular Catalysis, Instituto de Química, Departamento de Química Orgânica, Universidade Federal do Rio Grande do Sul-Avenida Bento Gonçalves, 9500, CEP 91501-970, PO Box 15003, Porto Alegre, RS, Brazil |
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| Abstract: | A new simple and efficient methodology for reductive sulfur extrusion from 2,1,3-benzothiadiazole compounds has been developed using NaBH4 in the presence of catalytic amounts of CoCl2·6H2O (1 mol %). This method is an efficient alternative for the generation of various 1,4-disubstituted-2,3-diaminobenzene derivatives from 4,7-disubstituted-2,1,3-benzothiadiazoles. The diamines can be easily converted into 4,7-disubstituted-quinoxaline compounds by simple reaction with glyoxal-sodium bisulfite. |
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| Keywords: | Sulfur extrusion Benzothiadiazole |
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