P(RNCH2CH2)N: efficient catalysts for the cyanosilylation of aldehydes and ketones |
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Authors: | Brandon M. Fetterly |
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Affiliation: | Department of Chemistry, Iowa State University, Ames, IA 50011, USA |
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Abstract: | The 1,2-addition of trialkylsilylcyanides to aldehydes and ketones produces the corresponding protected cyanohydrins in good to excellent yields when carried out at 0 °C to room temperature in the presence of catalytic amounts of the nonionic strong base P(RNCH2CH2)N (R = Me, i-Pr) in THF. These catalysts are easily removed from the product by hydrolysis or column filtration through silica gel. |
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Keywords: | Proazaphosphatrane Aldehyde Ketone Trimethylsilylcyanide Cyanohydrin |
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