Design, synthesis and evaluation of a fluorescent peptidyl sensor for the selective recognition of arsenite |
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Authors: | Katy J Parker |
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Institution: | Chemical Engineering and Applied Chemistry, Aston University, Aston Triangle, Birmingham B4 7ET, UK |
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Abstract: | A series of fluorescently labelled phytochelatin-like peptide sequences has been designed and synthesised as molecules with the ability both to bind to arsenite and to report this binding event. The peptides have been evaluated against a panel of biologically significant ions. The results of these initial studies are reported herein, and a structure which displays selectivity for As(III) over As(V) and other anions has been identified. |
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Keywords: | Arsenic Arsenite Peptide sensor Fluorescence |
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