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Efficient fluoride-mediated synthesis of 5-alkyl amino- and ether-substituted pyrazoles |
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| Authors: | Andrei Shavnya Martha L. Minich Bryson Rast Kristin Lundy DeMello Burton H. Jaynes |
| Affiliation: | Veterinary Medicine Research and Development, Pfizer Inc., Groton, CT 06340, USA |
| Abstract: | Fluoride-mediated nucleophilic substitution reactions of 1-(4-methylsulfonyl (or sulfonamido)-2-pyridyl)-5-chloro-4-cyano pyrazoles with various amines and alcohols occur under mild conditions to provide the 5-alkyl amino and ether pyrazoles in moderate to high yields. |
| Keywords: | Pyrazoles COX-2 inhibitors Fluoride mediated |
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