Regioselective lithium-halogen exchange and palladium-catalyzed cross-coupling reactions of 2,4-dihaloquinolines |
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| Authors: | Daniel L. Comins Jason M. Nolan Ibrahim D. Bori |
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| Affiliation: | Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA |
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| Abstract: | Lithium-halogen exchange of 2,4-dibromoquinolines proceeds regioselectively at C-4 and affords 4-substituted quinolines on quenching with electrophiles. Palladium-catalyzed cross-coupling reactions of 2-bromo-4-iodoquinoline provide 4-substituted 2-bromoquinoline derivatives. |
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| Keywords: | Lithium-halogen exchange Quinolines Cross-coupling α-Amino alkoxide |
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