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Regioselective lithium-halogen exchange and palladium-catalyzed cross-coupling reactions of 2,4-dihaloquinolines
Authors:Daniel L. Comins  Jason M. Nolan  Ibrahim D. Bori
Affiliation:Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8204, USA
Abstract:Lithium-halogen exchange of 2,4-dibromoquinolines proceeds regioselectively at C-4 and affords 4-substituted quinolines on quenching with electrophiles. Palladium-catalyzed cross-coupling reactions of 2-bromo-4-iodoquinoline provide 4-substituted 2-bromoquinoline derivatives.
Keywords:Lithium-halogen exchange   Quinolines   Cross-coupling   α-Amino alkoxide
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