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A versatile protocol for the preparation of substituted 1- and 2-naphthyl piperazines from aminonaphthols |
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| Authors: | Ana B. Bueno Claire J. Flynn Alicia Marcos Warren Porter |
| Affiliation: | a Lilly SA, Avda. de la Industria, 30, 28108 Alcobendas, Madrid, Spain b Eli Lilly & Co. Ltd, Lilly Research Centre, Erl Wood Manor, Windlesham, Surrey GU20 6PH, UK c Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA |
| Abstract: | Aminonaphthols are easily transformed into a variety of 1- and 2-naphthyl piperazines using a sequence of diazotization, iodide substitution and Pd(0) catalyzed coupling reactions. |
| Keywords: | Diazotization Palladium coupling |
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