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Atomarianones A and B: two cytotoxic meroditerpenes from the brown alga Taonia atomaria |
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| Authors: | Dennis Abatis Dimitrios Galanakis Dimitri Moreau Vassilios Roussis |
| Institution: | a University of Athens, School of Pharmacy, Department of Pharmacognosy and Chemistry of Natural Products, Panepistimiopolis Zografou, Athens 157 71, Greece b Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 541 24, Greece c National Museum of Natural History, Smithsonian Institution, Department of Botany, NHB 166, PO Box 37012, Washington, DC 20013-7012, USA d ISOMer, Laboratoire de Pharmacogénomique Marine, Faculté de Pharmacie, 1 Rue Gaston Veil, F-44035 Nantes, France |
| Abstract: | Two novel cyclized meroditerpenoids atomarianones A, and B (1 and 2), were isolated from the organic extract of the brown alga Taonia atomaria collected at Serifos island in the Central Aegean Sea. This is only the second report on metabolites having a functionalized indane moiety instead of a benzofurano- or a benzopyrano-ring connecting their aromatic and diterpenoid parts. Atomarianone A contains an unprecedented cis B-C ring fusion while atomarianone B is the epimer of A at C-7. Both metabolites were found to exhibit significant cytotoxic activity against two lung cancer cell lines. |
| Keywords: | Taonia atomaria Meroditerpenes Atomarianones Cytotoxic Chemotaxonomy |
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