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A highly enantioselective catalyst for asymmetric hydroformylation of [2.2.1]-bicyclic olefins |
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| Authors: | Jinkun Huang Emilio Bunel Alan Allgeier Jason Tedrow Thomas Storz J Preston Tiffany Correll Deana Manley Troy Soukup Randy Jensen Rashid Syed George Moniz Robert Larsen Michael Martinelli Paul J Reider |
| Institution: | Chemical Process Research & Development, Amgen Inc., One Amgen Center Dr., Thousand Oaks, CA 91320, USA |
| Abstract: | Rh(CO)2(acac)/TangPhos was found to be a highly enantioselective catalyst for asymmetric hydroformylation of norbornylene under mild conditions. Application of the protocol to the desymmetrization of other 2.2.1]-bicyclic olefins gave moderate to excellent enantioselectivity (55-92% ee). |
| Keywords: | Asymmetric hydroformylation TangPhos [2 2 1]-Bicyclic olefin |
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