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A new approach to the facile synthesis of mono- and disubstituted quinazolin-4(3H)-ones under solvent-free conditions |
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| Authors: | Peyman Salehi Minoo Dabiri Mostafa Baghbanzadeh |
| Institution: | a Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, PO Box 19835-389, Evin, Tehran, Iran b Department of Chemistry, Faculty of Sciences, Shahid Beheshti University, Evin, Tehran, Iran c Department of Chemistry, Faculty of Sciences, Bu-Ali Sina University, Hamadan, Iran |
| Abstract: | Quinazolin-4(3H)-one derivatives were synthesized successfully via a one-pot, three component reaction of isatoic anhydride and an orthoester with ammonium acetate or a primary amine catalyzed by silica sulfuric acid under solvent-free conditions. This is the first report on the synthesis of 2-substituted quinazolin-4(3H)-ones by this procedure. |
| Keywords: | Quinazolin-4(3H)-ones Silica sulfuric acid Catalysis Solvent free |
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