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Asymmetric synthesis of the pyran antibiotic (−)-centrolobine |
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| Authors: | S Chandrasekhar S Jaya Prakash T Shyamsunder |
| Institution: | Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India |
| Abstract: | An expedient total synthesis of (−)-centrolobine is achieved involving asymmetric Keck allylation and stereoselective intramolecular oxy-Michael reactions as key steps in 8% overall yield. |
| Keywords: | Keck allylation Intramolecular oxy-Michael reaction (&minus )-Centrolobine 2 6-Disubstituted tetrahydropyran |
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