A practical procedure for the selective N-alkylation of 4-alkoxy-2-pyridones and its use in a sulfone-mediated synthesis of N-methyl-4-methoxy-2-pyridone |
| |
| Authors: | David Conreaux Nuno Monteiro Philippe Desbordes |
| |
| Affiliation: | a Laboratoire de Chimie Organique 1, CNRS UMR 5181, Université Claude Bernard—Lyon I, ESCPE. 43, Bd du 11 Novembre 1918, 69622 Villeurbanne, France
b Bayer CropScience, 14 /20 rue Baizet, BP9163, 69623 Lyon Cedex 09, France |
| |
| Abstract: | It has been found that selective N-alkylation of 4-alkoxy-2-pyridones can be achieved under anhydrous, mild conditions with tetrabutylammonium iodide and potassium tert-butoxide being employed as the catalyst and the base, respectively. The procedure was applied to the preparation of 4-methoxy-1-methyl-2-pyridone, a valuable building block for heterocycle synthesis. |
| |
| Keywords: | 4-Alkoxy-2-pyridones N-Alkylation Tetrabutyl ammonium iodide Desulfonylation |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
