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New sesquiterpene lactones from water extract of the root of Lindera strychnifolia with cytotoxicity against the human small cell lung cancer cell, SBC-3 |
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| Authors: | Takamasa Ohno Munehiro Nakagawa Yun-Mo Li Hajime Mizukami |
| Institution: | a Department of Oriental Medicine, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan b College of Pharmacy, Kinjogakuin University, 2-1723 Ohmori, Moriyama-ku, Nagoya 463-8521, Japan c Second Department of Internal Medicine, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan d Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, 1-100 Kusumoto-cho, Chikusa-ku, Nagoya 464-8650, Japan e Laboratory of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuhoku, Nagoya 467-8603, Japan |
| Abstract: | In the present study, new sesquiterpene lactones (1) and (2) were isolated from the EtOAc soluble fraction of the water extract of Linderae Radix through bioassay-guided fractionation and isolation methods. The structure of these compounds was elucidated by spectroscopic analysis of their 2D NMR spectra, including COSY, HMBC, and HMQC techniques. Two isolates showed significant cytotoxicity against the human small cell lung cancer cell SBC-3, and lesser cytotoxicity against mouse fibroblast cell 3T3-L1. |
| Keywords: | Lindera strychnifolia Lauraceae Sesquiterpene lactone Antitumor activity |
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