New synthetic methodology for 3-aminotropones |
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Authors: | Á ngel M. Montañ a,Juan A. Barcia |
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Affiliation: | Unidad de Química Orgánica Industrial y Aplicada, Departamento de Química Orgánica, Facultad de Química, Universidad de Barcelona, Martí i Franquès, 1-11, 08028 Barcelona, Spain |
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Abstract: | A new synthetic methodology for 3-aminotropones is described. Tropones and 3-aminotroponic building blocks, present in a number of active natural products, could be prepared by a two step synthetic pathway: a first step consisting in a [4+3] cycloaddition reaction between a conveniently substituted α,α′-dihaloketone and a furan derivative functionalized on C-2 by a protected amino group. The second step is based on a rearrangement of the cycloadduct, via the cleavage of the oxygen bridge, under basic conditions. |
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Keywords: | [4+3] Cycloaddition 3-Aminotropones 8-Oxabicyclo[3.2.1]oct-6-en-3-one Oxygen bridge cleavage Rearrangement under basic conditions |
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