Synthesis of 3,4-disubstituted piperidines by ene cyclisation of 4-aza-1,7-dienes |
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| Authors: | Stephen M. Walker |
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| Affiliation: | School of Chemistry, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK |
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| Abstract: | Ene cyclisation of a variety of 4-aza-1,7-dienes affords 3,4-disubstituted piperidines. In particular, cyclisation of diesters 14 and 20 catalysed by MeAlCl2 gives the corresponding trans 3,4-disubstituted piperidines with diastereomeric ratios of >200:1. |
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| Keywords: | Piperidine Ene Cyclisation |
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