A highly efficient, asymmetric synthesis of blastidic acid: the β-amino acid component of the antibiotic, (+)-blasticidin S |
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| Authors: | Roland Bischoff |
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| Affiliation: | WestChem, Department of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK |
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| Abstract: | A new approach for the asymmetric synthesis of blastidic acid, the β-amino acid component of the antibiotic, (+)-blasticidin S has been achieved in 11 steps and 30% overall yield. The key transformations involve a one-pot Swern/Wittig reaction sequence to prepare the carbon backbone followed by a stereoselective conjugate addition to introduce the β-amino functionality. |
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| Keywords: | Blastidic acid β-Amino acid Antibiotic Asymmetric synthesis Conjugate addition |
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