| 低聚水溶性壳聚糖修饰阿魏酸及细胞毒活性研究 |
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| 引用本文： | 张慧,何玉凤,宋精峰,宋鹏飞,王荣民,丁兰,刘国安.低聚水溶性壳聚糖修饰阿魏酸及细胞毒活性研究[J].化学研究与应用,2006,18(12):1417-1420. |
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| 作者姓名： | 张慧 何玉凤 宋精峰 宋鹏飞 王荣民 丁兰 刘国安 |
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| 作者单位： | 1. 西北师范大学甘肃省高分子材料重点实验室,甘肃,兰州,730070
2. 西北师范大学生命科学学院,甘肃,兰州,730070 |
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| 摘 要： | 阿魏酸（Ferulic acid，FA），化学学名为4-羟基3-甲氧基苯丙烯酸，是当归、川芎、木贼、升麻、樟白皮等中药材水溶性提取物中主要的单体活性成份，属天然酚酸类化合物，由于其优良的抗氧化性，故对一些肿瘤表现出抑制作用，但活性不是很好。另外，由于FA的稳定性差，在人体内不参与肝肠循环等缺陷也影响其药效的发挥。
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| 关 键 词： | 阿魏酸 壳聚糖 SRB |
| 文章编号： | 1004-1656（2006）12-1417-04 |
| 收稿时间： | 2005-12-19 |
| 修稿时间： | 2006-05-26 |
Chitooligosaccharide conjugate ferulic acid and their cytotoxic activities for tumor cells |
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| ZHANG Hui,HE Yu-feng,SONG Jin-feng,SONG Peng-fei,WANG Rong-min,DING Lan,LIU GOU-An.Chitooligosaccharide conjugate ferulic acid and their cytotoxic activities for tumor cells[J].Chemical Research and Application,2006,18(12):1417-1420. |
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| Authors: | ZHANG Hui HE Yu-feng SONG Jin-feng SONG Peng-fei WANG Rong-min DING Lan LIU GOU-An |
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| Institution: | 1. Gansu Key Laboratory of Polymer Materials,Northwest Normal University,Lanzhou 730070 ; 2. College of Life Science,Northwest Normal University,Lanzhou 730070 |
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| Abstract: | Ferulic acid(FA)has been reported possessing strong bioactivities in physiology and pharmacology.In this paper,FA was conjugated into Chitooligosaccharide(COS)to get the polymer derivatives of FA.Their cytotoxic activities have been evaluated in vitro using SRB(sulforllodamine B)assay.In contrast of FA,the derivatives showed stronger cytotoxic activites than that of COS and FA. |
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| Keywords: | ferulic acid chitooligosaccharide SRB cytotoxic activities |
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