Novel one-pot total syntheses of deoxyvasicinone, mackinazolinone, isaindigotone, and their derivatives promoted by microwave irradiation |
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| Authors: | Liu Ji-Feng Ye Ping Sprague Kevin Sargent Katie Yohannes Daniel Baldino Carmen M Wilson Christopher J Ng Shi-Chung |
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| Affiliation: | ArQule, Inc., Woburn, Massachusetts 10801, USA. |
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| Abstract: | [reaction: see text]. Total syntheses of deoxyvasicinone (1), mackinazolinone (2), and 8-hydroxydeoxyvasicinone (3) via novel microwave-assisted domino reactions, as well as a novel three-component one-pot total synthesis of isaindigotone (5) promoted by microwave irradiation, are reported. The efficient reaction process enabled us to rapidly access related natural product derivatives and to identify a new class of cytotoxic agents. |
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