Catalytic enantioselective oxaziridination |
| |
| Authors: | Lykke Lennart Rodríguez-Escrich Carles Jørgensen Karl Anker |
| |
| Institution: | Center for Catalysis, Department of Chemistry, Aarhus University, Aarhus C, Denmark. |
| |
| Abstract: | The first catalytic enantioselective synthesis of oxaziridines is presented. The oxidation of aryl and alkyl aldimines with m-CPBA under organocatalytic conditions using cinchona alkaloid-derived catalysts furnished optically active oxaziridines in good yields and high enantioselectivities (up to 94% ee). Mechanistic investigations indicate a stepwise enantioselective oxidation process. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
