Because of the complexity of monomer sequence formation during polymerization, it is necessary to employ programmed synthesis to prepare copolymers with well‐defined sequences. We introduce a computational tool that can generate recipes to synthesize copolymers with pre‐designed monomer sequences. An efficient design strategy was crafted based on analyzing the impact of varying multiple synthesis factors in forced gradient copolymerization on the targeted properties. Finally, the proposed design tool was applied to generate recipes for several different structural gradient copolymers as case studies. It was shown that a recipe that meets certain targets can be designed in minutes. The recipes that are designed can also be tailored according to different application requirements.
