On the thermal behaviour of acetylphenyl-hydroxyaceticacid-4-nitrobenzyl esters |
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| Authors: | Th Beyrich M Schleuder G Mietz H Wulff M Gruno |
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| Institution: | (1) Department of Pharmacy, Institute of Drug Control, Institute of Physical Chemistry of Ernst Moritz Arndt University of Greifswald, Germany;(2) Department of Chemistry, Institute of Physical Chemistry of Ernst Moritz Arndt University of Greifswald, Germany |
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| Abstract: | The 4-nitrobenzyl ester of acetylphenylhydroxyacetic acid differs in its melting behaviour from other nitrobenzyl esters of phenylhydroxyacetic or acetylphenylhydroxyacetic acids, the racemate having a higher melting point than the enantiomers. By means of thermal analysis, IR spectroscopy and X-ray diffractometry the ester can be shown to occur in two crystalline modifications. In the process of solidification of the molten mass, at first a modification of higher energy is formed, obviously being caused by an excess of one enantiomer, which is then exothermally rearranged in the lattice of the racemate. |
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| Keywords: | acetylphenylhydroxyaceticacid-4-nitrobenzyl esters enantiomer racemat thermal behaviour |
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