| DISCO法构建ALS抑制剂与受体作用的药效团模型 |
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| 引用本文： | 缪方明,苏华庆,王瑾玲,李爱秀.DISCO法构建ALS抑制剂与受体作用的药效团模型[J].物理化学学报,2000,16(10):926-931. |
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| 作者姓名： | 缪方明 苏华庆 王瑾玲 李爱秀 |
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| 作者单位： | Institute of Crystallography of Tianjin Normal University,Tianjin 300074,Medical Collage of Chinese People's Armed Police,Tianjin 300162 |
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| 摘 要： | 在受体ＡＬＳ三维结构未知的情况下，利用距离比较法（ＤＩＳＣＯ）对四个结构特征判别较大的ＡＬＳ抑制型除草剂进行了研究，构建了该类除草剂与受体作用的可能的药效团模型，为进一步设计开发新型的ＡＬＳ抑制剂及模拟靶蛋白的活性空腔提供有意义的参考。
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| 关 键 词： | ALS抑制剂 距离比较法(DISCO) 除草剂 药效团模型 |
| 收稿时间： | 2000-02-08 |
| 修稿时间： | 2000-06-06 |
Pharmacophore Model of ALS Inhibitors by DISCO Method |
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| Miao Fanming,Su Huaqing,Wang Jinling,Li Aixiu.Pharmacophore Model of ALS Inhibitors by DISCO Method[J].Acta Physico-Chimica Sinica,2000,16(10):926-931. |
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| Authors: | Miao Fanming Su Huaqing Wang Jinling Li Aixiu |
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| Institution: | Institute of Crystallography of Tianjin Normal University,Tianjin 300074|Medical Collage of Chinese People's Armed Police,Tianjin 300162 |
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| Abstract: | In this paper Pharmacophore Models of the interaction of four varieties of ALS inhibitors by distance comparison (DISCO) method with unknown three-dimensional structure of the receptor are reported. The Model not only conforms to our research requirement, but also helps to find a lot of unexpected biological information,which provides a theoretical guidance for the further design of new and more active ALS inhibitory herbicides and the active cavity simulation of its receptors. |
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| Keywords: | ALS inhibitors DISCO Herbicide Pharmacophore Model |
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