| Short Synthesis of C-terminal Modified Peptides by a Series-connection Procedure |
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| 引用本文： | GuiJieTIAN ChuanLiangQIU ZheLIU DeXinWANG. Short Synthesis of C-terminal Modified Peptides by a Series-connection Procedure[J]. 中国化学快报, 2005, 16(1): 31-34 |
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| 作者姓名： | GuiJieTIAN ChuanLiangQIU ZheLIU DeXinWANG |
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| 作者单位： | InstituteofMateriaMedicaChineseAcademyofMedicalSciencesandPekingUnionMedicalCollege,Beijing100050 |
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| 摘 要： | Three peptide alcohols and four peptidyl N-akyl-amides were prepared by a series-connection procedure consisting of n-1 sequencial assembly on solid support followed by ammonolysis with glycinol, benzylamine or n-butylamine, and successive extractionelution through C-18 layer. All products were obtained from this procedure without further purification,in an overall yield of 75-86%.
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| 关 键 词： | 固相合成 C-末端改性 缩氨酸 氨解作用 缩氨醇 |
Short Synthesis of C-terminal Modified Peptides by a Series-connection Procedure |
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| Gui Jie TIAN,Chuan Liang QIU,Zhe LIU,De Xin WANG Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing. Short Synthesis of C-terminal Modified Peptides by a Series-connection Procedure[J]. Chinese Chemical Letters, 2005, 16(1): 31-34 |
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| Authors: | Gui Jie TIAN Chuan Liang QIU Zhe LIU De Xin WANG Institute of Materia Medica Chinese Academy of Medical Sciences Peking Union Medical College Beijing |
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| Affiliation: | Gui Jie TIAN,Chuan Liang QIU,Zhe LIU,De Xin WANG* Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050 |
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| Abstract: | Three peptide alcohols and four peptidyl N-akyl-amides were prepared by a series-connection procedure consisting of n-1 sequencial assembly on solid support followed by ammonolysis with glycinol, benzylamine or n-butylamine, and successive extractionelution through C-18 layer. All products were obtained from this procedure without further purification, in an overall yield of 75-86%. |
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| Keywords: | Ammonolysis C-18 filtration solid-phase synthesis. |
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