Recent advances in electric analysis of cells in microfluidic systems |
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Authors: | Ning Bao Jun Wang Chang Lu |
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Institution: | (1) Department of Agricultural and Biological Engineering, Purdue University, 225 South University Street, West Lafayette, IN 47907, USA |
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Abstract: | Microfluidics offers an ideal platform to integrate cell-based assays with electric measurements. The technological advances
in microfluidics, microelectronics, electrochemistry, and electrophysiology have greatly inspired the development of microfluidic/electric
devices that work with a low number of cells or single cells. The applications of these microfluidic systems range from the
detecting of cell culture density to the probing of cellular functions at the single-cell level. In this review, we introduce
the recent advances in the electric analysis of cells on a microfluidic platform, specifically related to the quantification
and monitoring of cells in static solution, on-chip patch-clamp measurement, and examination of flowing cells. We also point
out future directions and challenges in this field.
Figure Different microfluidic devices applied to electrical analysis of cells |
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Keywords: | Microfluidics Electric analysis Patch-clamp Flow cytometry Single-cell analysis |
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