1-(Trifluoromethyl)-3,4-dihydropyrrolo-[1,2-<Emphasis Type="Italic">a</Emphasis>] pyrazines: synthesis and reactions with O- and N-nucleophiles |
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Authors: | V I Terenin M V Galkin E V Kabanova A S Ivanov |
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Institution: | (1) M. V. Lomonosov State University, Moscow, 119992, Russia |
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Abstract: | The method of synthesis has been developed and reactions of 1-(trifluoromethyl)-3,4-dihydro-pyrrolo1,2-a]pyrazines with O-
and N-nucleophiles have been studied. It was found that reactions of nucleophiles with 1-(trifluoro-methyl)pyrrolo1,2-a]pyrazines
transforms the trifluoromethyl group to amide and amidine groups together with aromatization of the pyrrolo1,2-a]pyrazine
system as a result of the formal elimination of a molecule of hydrogen fluoride. |
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Keywords: | |
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