1-(Trifluoromethyl)-3,4-dihydropyrrolo-[1,2-<Emphasis Type="Italic">a</Emphasis>] pyrazines: synthesis and reactions with O- and N-nucleophiles

The method of synthesis has been developed and reactions of 1-(trifluoromethyl)-3,4-dihydro-pyrrolo1,2-a]pyrazines with O- and N-nucleophiles have been studied. It was found that reactions of nucleophiles with 1-(trifluoro-methyl)pyrrolo1,2-a]pyrazines transforms the trifluoromethyl group to amide and amidine groups together with aromatization of the pyrrolo1,2-a]pyrazine system as a result of the formal elimination of a molecule of hydrogen fluoride.