Iodine-catalyzed direct allylation of chiral oxazolidinones by the amide-aldehyde-alkene condensation |
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| Authors: | Tong-Lin Wang Hai-Tang Qi Xi-Cun Wang Zheng-Jun Quan |
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| Affiliation: | 1. College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, People’s Republic of China;2. Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Lanzhou, Gansu 730070, People’s Republic of China |
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| Abstract: | An iodine-catalyzed direct allylation of chiral oxazolidinones with aldehydes and alkenes has been developed. The reaction proceeds, without use of any bases or metals, directly converted the 3-chiral oxazolidinones into N-allylated oxazolidinones. Additionally, the 3-chiral allylamine skeleton was constructed and the diastereomers were isolated by simple column chromatography. |
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| Keywords: | Corresponding author. Chiral oxazolidinones Chiral allylamine Amide-aldehyde-alkene condensation Iodine catalyst |
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