Bismuth-catalyzed methylation and alkylation of quinone derivatives with tert-butyl peroxybenzoate as an oxidant |
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Authors: | Jian Yang Yu Dong Shuai He Zhi-Chuan Shi Yu Wang Ji-Yu Wang |
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Affiliation: | 1. Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, PR China;2. University of Chinese Academy of Sciences, Beijing 100049, PR China;3. Southwest Minzu University, Chengdu 610041, PR China;4. Guizhou Education University, Guiyang 550018, PR China |
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Abstract: | A bismuth-catalyzed methylation of quinones in the presence of tert-butyl peroxybenzoate (TBPB) was developed via a radical reaction mechanism. Particularly, TBPB was used not only as an efficient oxidant, but also as a green methyl source in such transformation. Moreover, this method could also be efficiently extended to the alkylation of quinones. This reaction tolerated a series of functional groups and prepared a series of derivatives of vitamin K3 and benzoquinone. Notably, antimalarial parvaquone was synthesized by the reaction. |
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Keywords: | Corresponding author. Quinone derivatives Methylation Alkylation Bismuth (III) trifluoromethanesulfonate |
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