Palladium-catalyzed decarboxylative aminocarbonylation with alkynoic acid and tertiary amine for the synthesis of alkynyl amide |
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| Authors: | Muhammad Aliyu Idris Myungjin Kim Jeung Gon Kim Sunwoo Lee |
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| Institution: | 1. Department of Chemistry, Chonnam National University, Gwangju 61186, Republic of Korea;2. Department of Chemistry and Research Institute of Physics and Chemistry, Chonbuk National University, Jeonju 54896, Republic of Korea |
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| Abstract: | We developed a method for the synthesis of alkynyl amides via the carbonylation of alkynoic acids and C-N activation of tertiary amines. The reaction of alkynoic acid and tertiary amine with carbon monoxide using a palladium catalyst in the presence of oxygen, KI, and K3PO4, gave the desired alkynyl amides in good yields. |
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| Keywords: | Corresponding author Alkynyl amide Carbonylation Tertiary amine Decarboxylative coupling Propiolic acids |
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