Synthesis of ferrocene annulated trifluoromethylated heterocycles with crispine and lamellarin skeletons |
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| Authors: | Vladislav Y Korotaev Igor B Kutyashev Alexey Y Barkov Yuliya S Rozhkova Irina V Plekhanova Yurii V Shklyaev Vyacheslav Y Sosnovskikh |
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| Institution: | 1. Institute of Natural Sciences and Mathematics, Ural Federal University, 620000 Ekaterinburg, Russian Federation;2. Institute of Technical Chemistry, Russian Academy of Sciences (Ural Branch), 614013 Perm, Russian Federation |
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| Abstract: | Ferrocene analogues of pyrrolo2,1-a]isoquinoline alkaloids, 2-(trifluoromethyl)-5,6-dihydroferrocenog]indolizine and 6-(trifluoromethyl)-8,9-dihydro-6H-chromeno4,3-b]ferrocenog]indolizines, were obtained in 44–65% yield via the Grob reaction between 1-nitro-1-(2,2,2-trifluoroethylidene)alkanes or 3-nitro-2-(trifluoromethyl)-2H-chromenes and 1-alkyl-3,4-dihydroferrocenoc]pyridines in 2-propanol at reflux. |
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| Keywords: | Corresponding author 1-Nitro-1-(2 2 2-trifluoroethylidene)alkanes Grob reaction |
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