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One-pot diastereoselective synthesis of tetrahydroepimino-benzo[b]azocines through sequential [3+2]-cycloaddition and Staudinger-aza-Wittig reactions |
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| Authors: | Xiaoming Ma Xiaofeng Zhang Guoshu Xie John Mark Awad Wei Zhang |
| Institution: | 1. School of Pharmaceutical Engineering and Life Science, Changzhou University, Changzhou 213164, China;2. Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Boulevard, Boston, MA 02125, USA;3. Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Boston, MA 02215, USA |
| Abstract: | The one-pot synthesis of tetrahydro-epiminobenzob]azocines through a sequential 1,3-dipolar cycloaddition and intramolecular Staudinger-aza-Wittig reaction sequence is reported. This methodology provides a new and efficient approach for medium-sized and bridged nitrogen heterocyclic molecules. |
| Keywords: | Corresponding author One-pot synthesis [3+2] Cycloaddition Aza-Wittig reaction |
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