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From acylethynylpyrroles to pyrrole-pyrone ensembles in a one step |
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| Authors: | Maxim D Gotsko Ivan V Saliy Lyubov&#x; N Sobenina Igor A Ushakov Boris A Trofimov |
| Institution: | A.E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 Favorsky St., Irkutsk 664033, Russian Federation |
| Abstract: | Functionalized pyrrole-pyrone ensembles have been synthesized in up to 87% yields by KOH/MeCN 4+2]-cyclization of available acylethynylpyrroles with methylene active esters. The synthesized compounds, due to their potential rich chemistry, are rewarding building blocks for novel pyrrole-integrated complex molecules and promising precursors of medicine targeted compounds. |
| Keywords: | Corresponding author Acylethynylpyrroles Methylene active esters Nucleophilic addition Pyrrole-pyrones |
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