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New approaches to the synthesis of benzo[h]pyrroloisoquinoline derivatives |
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| Authors: | Anastasia A Ershova Anna D Zinoveva Tatiana N Borisova Alexander A Titov Alexey V Varlamov Leonid G Voskressensky Van Tuyen Nguyen Tuan Anh Le |
| Institution: | 1. Organic Chemistry Department, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation;2. Institute of Chemistry, Graduate University of Science and Technology Vietnam Academy of Science and Technology, N. 18, Hoang Quoc Viet Street, Can Giay, Hanoi, 100 000, Vietnam;3. Faculty of Chemistry, VNU University of Science, N. 19, Le Thanh Tong Street, Hanoi, 100 000, Vietnam |
| Abstract: | An effective strategy for the synthesis of benzoh]pyrrolo2,1-a]isoquinoline derivatives has been developed. The process can be described as a one-pot domino reaction that consists of an initial Michael addition, intramolecular cyclization, and subsequent transformations leading to the formation of the desired products. A wide range of structurally diverse hydrogenated benzoh]pyrrolo2,1-a]isoquinolines were obtained in 34–98% yield. This strategy represents an efficient catalyst-free procedure that allows the synthesis of previously inaccessible compounds. |
| Keywords: | Corresponding author Alkaloids Anticancer activity Domino reaction |
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