Chiral copper-catalyzed enantioselective Michael difluoromethylation of arylidene meldrum's acids with (difluoromethyl)zinc reagents |
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| Authors: | Yu Endo Koki Ishii Koichi Mikami |
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| Institution: | Department of Chemical Science and Engineering, School of Materials and Chemical Technology, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo, 152-8552, Japan |
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| Abstract: | The catalytic enantioselective difluoromethylation of arylidene Meldrum's acids with (difluoromethyl)zinc reagent, easily prepared through zinc/iodide exchange reaction of difluoroiodomethane and diethylzinc with co-solvent such as pyridines, by a chiral phosphoramidite-Cu catalyst is shown to provide highly enantioselective sp 3]-difluoromethyl Michael addition product in good yields and high levels of enantioselectivity. |
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| Keywords: | Corresponding author |
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