Simple and rapid p-methoxybenzylation of hydroxy and amide groups at room temperature by NaOt-Bu and DMSO |
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Authors: | Shohei Hamada Koichi Sugimoto Masashi Iida Takumi Furuta |
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Affiliation: | Department of Pharmaceutical Chemistry, Kyoto Pharmaceutical University, Yamashinaku, Kyoto 607-8414, Japan |
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Abstract: | The p-methoxybenzylation of hydroxy and amide groups by p-methoxybenzyl chloride utilizing NaOt-Bu in DMSO is described. p-Methoxybenzylation of sterically hindered menthol using NaOt-Bu in DMSO proceeded faster than the commonly used methods which use NaH in THF or DMF for p-methoxybenzylation of hydroxy and amide groups. The described method was applicable for sterically hindered substrates at room temperature without adding any activating reagents such as tetrabutylammonium iodide. |
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Keywords: | Corresponding author. DMSO Protecting group |
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