Three new dibromopyrrole alkaloids from the South China Sea sponge Agelas nemoechinata |
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| Authors: | Tao Li Ping-Lin Li Xiang-Chao Luo Xu-Li Tang Guo-Qiang Li |
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| Affiliation: | 1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People''s Republic of China;2. Laboratory of Marine Drugs and Biological Products, National Laboratory for Marine Science and Technology, Qingdao 266235, People''s Republic of China;3. College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao 266100, People''s Republic of China |
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| Abstract: | Three new dibromopyrrole alkaloids, 9-N-methylcylindradine A (1), 1-N-methylugibohlin (2), nemoechine H (3), together with one known dibromopyrrole alkaloid N-methyldibromoisophakellin (4) were isolated from the South China Sea sponge Agelas nemoechinata. Their structures were elucidated by comprehensive spectroscopic methods including HRESIMS and NMR, and the absolute configuration of compound 1 was further confirmed by comparison of optical rotation. Compound 3 exhibited moderate cytotoxic activity against K562 and L-02 with IC50 values of 6.1 μM and 12.3 μM, respectively. |
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| Keywords: | Corresponding authors at: Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China (G. Li). Sponge Bromopyrrole alkaloids Cytotoxic activity |
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