Synthesis of both enantiomers of the docosahexaenoic acid ester of 13-hydroxyoctadecadienoic acid (13-DHAHLA) |
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| Authors: | Anders Vik Trond Vidar Hansen Ondrej Kuda |
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| Affiliation: | 1. Department of Pharmacy, Section for Pharmaceutical Chemistry, University of Oslo, PO Box 1068 Blindern, N-0316 Oslo, Norway;2. Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Prague, Czech Republic |
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| Abstract: | Recently, several different classes of endogenous lipids have been reported that display antidiabetic and anti-inflammatory effects. Due to their minute presence in human samples, access to synthetic material of each enantiomer becomes necessary for exact structural elucidation and extensive biological evaluation. Herein we report the multi-milligram synthesis of both enantiomers of the docosahexaenoic acid ester of 13-hydroxyoctadecadienoic acid (13-DHAHLA) from commercially available starting materials. |
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| Keywords: | Corresponding author. 13-DHAHLA 13-HODE FAHFAs Schwarz’s reagent Boland reduction |
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