An efficient Darzens reaction promoted by 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) |
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| Authors: | Juan Luo Lanfang Hu Minghao Zhang Qiang Tang |
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| Affiliation: | College of Pharmacy, Center for Lab Teaching and Management, Chongqing Research Center for Pharmaceutical Engineering, Chongqing Medical University, No. 1 Yixueyuan Road, Chongqing 400016, PR China |
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| Abstract: | An efficient DBU promoted Darzens reaction utilising α-haloketones containing an enolizable α′-hydrogen is reported. This method diastereoselectively afforded the corresponding α,β-epoxy ketones good to excellent yields in an one-pot reaction without using any transition metals or additives. Furthermore, haloketones without an α′-hydrogen are also applicable in this reaction. |
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| Keywords: | Corresponding author. DBU Darzens reaction |
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