Synthetic studies towards the penicisulfuranols: Synthesis of an advanced spirocyclic diketopiperazine intermediate |
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| Authors: | Kevin M Gayler Kyle M Lambert John L Wood |
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| Institution: | Department of Chemistry and Biochemistry, Baylor University, Waco, TX, 76798, USA |
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| Abstract: | The 2,5-diketopiperazine (DKP) moiety is a core feature of many natural products and medicinally relevant scaffolds. As part of our efforts directed towards a total synthesis of penicisulfuranol B, we have developed and report herein: (1) the preparation of an N-hydroxy diketopiperazine intermediate accessible via a molybdenum-mediated oxidation of a parent diketopiperazine, and (2) further synthetic studies leading to a novel spirocyclic dihydrobenzofuran-containing diketopiperazine. |
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| Keywords: | Corresponding author Penicisulfuranols Diketopiperazine Spirocycle Hydroxamic acid Oxidation |
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