Talarophenol sulfate and talarophilones from the Australian mud dauber wasp-associated fungus,Talaromyces sp. CMB-W045 |
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Authors: | Pabasara Kalansuriya Zeinab G Khalil Angela A Salim Robert J Capon |
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Institution: | Division of Chemistry and Structural Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia |
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Abstract: | Chemical analysis of a jasmine rice cultivation of an Australian mud dauber wasp-associated fungus, Talaromyces sp. CMB-W045, led to the discovery of a new p-terphenyl, talarophenol sulfate (1). The structure elucidation of 1 was achieved by detailed spectroscopic analysis supported by acid hydrolysis to the p-hydroquinone talarophenol (2), and subsequent in situ air oxidation to trace amounts of the p-quinone talaroquinone (3). The same jasmine rice cultivation also yielded the new talarophilones A (4) and B (5), and known (+)-mitorubrin (6) and pochonin D (7), with structures assigned by detailed spectroscopic analysis. Neither 1 or 4–7 exhibited growth inhibitory properties against a panel of human cell lines, or bacterial or fungal pathogens, although 1 did exhibit selective antibacterial activity against Streptococcus pyogenes ATCC 12344 (IC50 10 µM). |
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Keywords: | Corresponding author Talaromyces Talarophenol Talarophilones Antibacterial |
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