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Merging photoredox catalysis with transition metal catalysis: Direct C4-H amination of 8-hydroxyquinoline derivatives |
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| Authors: | Yueyue Ma Yaqi Shi Fan Yang Yusheng Wu Yangjie Wu |
| Institution: | 1. The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou, Henan, 450052, PR China;2. TetranovBiopharm, LLC. &Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou, Henan, 450001, PR China |
| Abstract: | A practical and efficient protocol for Ag/Ru-cocatalyzed regioselective C-H amination of 8-hydroxyquinoline esters with pyrazoles was developed, This reaction proceeded smoothly via a photoredox-mediated direct C-H/N-H oxidative coupling process. The remarkable features of this reaction include the wide substrate scope, mild reaction conditions and high regioselectivity at the C4 site of the quinolinyl moiety. |
| Keywords: | Corresponding author Ag/Ru-cocatalyzed Amination C-H/N-H oxidative coupling 8-Hydroxyquinoline esters |
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