Practical enantioselective synthesis of (3S, 4R)-3-hydroxypiperidine-4-carboxylic acid |
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| Authors: | Nathan J. Line |
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| Affiliation: | AMRI, 26 Corporate Circle, Albany, NY 12203, United States |
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| Abstract: | A practical enantioselective synthesis of (3S, 4R)-3-hydroxypiperidine-4-carboxylic acid was accomplished via an unconventional Evans anti-aldol reaction followed by a one-pot azide reduction/reductive cyclization. |
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| Keywords: | Piperidine Aldol Enantioselective synthesis Reductive cyclization |
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