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Stereoselective synthesis of novel functionalized cyclohexanone derivatives via the condensation of aromatic aldehydes with acetoacetamide and the influence of the ortho-effect and autocondensation |
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| Authors: | Vladimir L. Gein Natalia V. Nosova Andrei N. Yankin Alina Y. Bazhina Maksim V. Dmitriev | |
| Affiliation: | 1. Perm State Pharmaceutical Academy, Polevaya St. 2, 614990 Perm, Russian Federation;2. St. Petersburg State University, Universitetskaya nab. 7/9, 199034 St. Petersburg, Russian Federation;3. Perm State National Research University, Bukirev St. 15, 614990 Perm, Russian Federation | |
| Abstract: | A simple, inexpensive and stereoselective synthesis of novel functionalized cyclohexanone derivatives via the reaction of acetoacetamide with aromatic aldehydes in ethanol at room temperature is described. Additionally, the presence of substituents such as | |
| Keywords: | Corresponding author. Heterocycles Cyclohexanones Acetoacetamide Piperidines Autocondensation | |
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