|
|||||
|
|
Microwave-assisted multicomponent synthesis of julolidines using silica-supported calix[4]arene as heterogeneous catalyst |
|
| Authors: | Walysson Ferreira de Paiva Ingredy Bastos Braga João Vitor de Assis Sandra Milena Bonilla Castañeda Ángel Gabriel Sathicq Valeria Palermo Gustavo Pablo Romanelli Ricardo Natalino Marcio José da Silva Felipe Terra Martins Gustavo Senra Gonçalves de Carvalho Giovanni Wilson Amarante Sergio Antonio Fernandes |
| Affiliation: | 1. Grupo de Química Supramolecular e Biomimética (GQSB), Departamento de Química, CCE, Universidade Federal de Viçosa, Viçosa, MG, 36570-900, Brazil;2. Centro de Investigación y Desarrollo en Ciencias Aplicadas “Dr. Jorge J. Ronco” (CINDECA-CCT-CONICET), Universidad Nacional de La Plata, Calle 47, No 257, B1900AJK La Plata, Argentina;3. Instituto de Química, Universidade Federal de Goiás, Campus Samambaia, Goiânia, GO, CP 131, 74001-970, Brazil;4. Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora, MG, 36036-900, Brazil |
| Abstract: | The application of immobilizing calixarene onto the surface of silica using a sol-gel method, as an efficient heterogeneous catalyst (CX4SO3HSi(n)) for multicomponent Povarov reaction has been described. Catalytic activity of the CX4SO3HSi(n) for the synthesis of julolidines under greener and environmentally benign conditions in simple and efficient method was explored. Notably, only 0.5 mol% of the catalyst is sufficient to catalyze the Povarov solvent-free reaction under microwave-assistance. Besides, this protocol allows the construction of four new C–C bonds and two C–N bonds in a single step. To the best of our knowledge, this consists the first silica support calix[4]arene as a heterogeneous catalyst for multicomponent synthesis of julolidines. |
| Keywords: | Corresponding author. Calixarenes Heterogeneous catalysis Julolidines Microwave-assisted Multicomponent reactions |
| 本文献已被 ScienceDirect 等数据库收录！ | |